|
KMID : 0043320120350111999
|
|
Archives of Pharmacal Research
2012 Volume.35 No. 11 p.1999 ~ p.2006
|
|
|
Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: Histopathological aspects
|
|
Lee Dong-Won
Ku Sae-Kwang
Cho Hyuk-Jun
Kim Jeong-Hwan
Hiep Tran Tuan
Han Sang-Duk
Kim Bo-Gyun
Kang Min-Kyung
Do Eui-Seon
Jun Joon-Ho
Jang Sun-Woo
Son Mi-Won
Sohn Young-Taek
Choi Han-Gon
Yong Chul-Soon
|
|
|
Abstract
|
|
|
|
In this study, we evaluated the effects of silicone-based gel on the healing of hypertrophic scars in the rabbit ear model. After 4-week application of silicone-based gel containing allantoin, dexpanthenol and heparin (Noscarna™) to scars in a rabbit ear model of hypertrophic scarring, significant improvements in hypertrophic scar healing and a great loss of skin pigment were observed compared to the non-treated control, base or silicone control-treated scars. Furthermore, histological analysis of Noscarna™-treated scars revealed a significant reduction in scar elevation index (SEI), anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts compared to all control hypertrophic scars. Furthermore, Noscarna™ showed more favorable effects on hypertrophic scars than a commercial product, Contractubex®. Therefore, these results clearly demonstrated that the newly developed silicone-based gel, Noscarna™, could be a promising formulation as an effective therapeutic agent for hypertrophic scars.
|
|
|
KEYWORD
|
|
|
Silicone, Hypertrophic scar, Noscarna™, SEI, Gel
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|